GOF PSIMPipelines

Using our platform technology, we were able to develop orally absorbable insulin by modifying the surface charges of insulin without using more traditional techniques; enteric coating, absorption enhancers, nanoparticles, or liposomes. This modified insulin was found to have a GI absorption rate of 60-70%, making it a feasible peptide for diabetes treatment through oral administration. Insulin types that were studied included bovine insulin, porcine insulin and human recombinant insulins such as Lilly's Humalog and Sanofi's Lantus.

Alzheimer's disease is the most common dementia type and accounts for approximately 60-70% of dementia cases. The World Health Organization revealed that there are approximately 55 million people worldwide living with Alzheimer's disease or related dementia and there are nearly 10 million new cases every year. The global market for Alzheimer's disease treatment should grow from $4.8 billion in 2020 to $6.3 billion by 2025 with a compound annual growth rate (CAGR) of 5.5% during the period of 2020-2025. However, using our technology, we have discovered a drug candidate that targets multiple hallmarks of AD.

Using our GOF technology, we have made this protein and, as a result, have acquired a new biological activity which induces a strong apoptosis-inducing activity on cancer cells. To further characterize the possible bioactive peptides within the alpha-lactalbumin molecule (cryptides), a "peptide library" based on the amino acid sequence of this protein was constructed. Peptides 10 amino acids in length were chemically synthesized systematically starting from the N-terminal to the C-terminal ends of human lactalbumin. Once synthesized, each individual peptide was then treated with GOF technology and tested for its apoptosis-inducing activity. Among the peptides we synthesized, we have identified a peptide (4H) which corresponds to the amino acid #46-56 of human alpha-albumin that was able to induce apoptosis in various cancer cell lines.

When a human egg is fertilized by sperm, early cell division gives rise to the blastocyst (preimplantation embryo), which possesses a surrounding layer of cells known as a trophoblast. During the process of attachment between the blastocyst and uterine wall, trophoblasts express invasive behaviors similar to those found in cancer cells. Striking phenotypic and genotypic similarities exist between trophoblasts and cancer cells with respect to; cell functions, development, protection, and capacity to influence the host. As a result, the concept of trophoblastic-like transdifferentiation of cancer cells appears to be a rational proposal to explain this phenomenon. Should this concept be validated, it could pave the way for promising research and therapeutic approaches given that trophoblastic properties are vital for tumor growth although they are epigenetically inactive in normal cells.